loss

noun:the fact or process of losing something or someone
- The loss of her job was a significant setback.
noun:an amount of money lost by a business or organization
- The company reported a substantial loss for the fiscal year.
noun:the feeling of grief or sadness after losing someone or something of value
- He felt a profound sense of loss after his friend moved away.
noun:a person or thing that is badly missed when they are gone
- The retired captain was a great loss to the team.
noun:a defeat in a contest or game
- The team's loss in the championship was disappointing.